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Exp Neurol 222:191203

When an individual is healthy, AIM is in an inactivated state as a result of bonding with IgM, but when waste builds up in the body, AIM separates from IgM and bonds with the waste

Additionally, the specific BMP antagonist gremlin induces LOX and LOXL1-4 expression through constitutively active TGF/Smad and inducible MAPK/JNK signaling pathways, suggesting BMPs may at least partially mediate enzymatic collagen crosslinking (Sethi et al ., 2013)