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This increased glucose uptake [54]

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While the haem biosynthesis and degradation pathway has already been demonstrated to be synthetic lethal in FH-deficient cells, the role of GSH metabolism in FH-deficient cells has not been investigated before and required further investigation

The ratio of GSH to GSSG is a key indicator of cellular oxidative stress, with a healthy cell maintaining a ratio greater than 100:1 [2][5]