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Currently, STING agonists are usually used in high-dose intratumoral injections to treat tumors because of poor cell membrane permeability, poor targeting, poor stability, and low bioavailability, where hides inevitable side effects [24]

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316 Simultaneously, anterograde signals precisely control the ETC, TCA cycle enzymes, and ROS detoxification pathways by regulating nuclear-encoded mitochondrial protein expression

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