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Mitochondrial -oxidation of VPA involves its transport within 2 the mitochondrial matrix, using the same pathway as do long-chain fatty acids

214,215,216,217 Additionally, sensory neurons in the dorsal root ganglia (DRG) exhibit altered phenotypes, such as reduced neurofilament synthesis, endoplasmic reticulum stress, and changes in key plasticity molecules, such as growth-associated protein 43 (GAP43) and heat shock proteins, leading to mitochondrial dysfunction and loss of peripheral nerve function

Spreading depression triggers headache by activating neuronal panx1 channels

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Values in bold indicate significant P -values