Using the Global Assessment of Functioning (GAF) scale for adults, and the Children's Global Assessment Scale (CGAS) for children, the study team reported moderate improvements in overall functioning from the use of the supplements
In: Friends or enemies
1038) GovTrack.us"
Lab Invest 1991
T-cell protein tyrosine phosphatase (TCPTP), megakaryocyte protein tyrosine phosphatase (PTP-MEG2), and src homology phosphatase 2 7-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethoxy)-2-phenyl-4H-chromen-4-one - 7-(2-(4-nitro-1H-imidazol-1-yl)ethoxy)-2-phenyl-4H-chromen-4-one - 7-(2-(5-methyl-1H-tetrazol-1-yl)ethoxy)-2-phenyl-4H-chromen-4-one - 7-(2-bromoethoxy)-2-phenyl-4H-1-benzopyran-4-one - 7-(3-(4-nitro-1H-imidazol-1-yl)propoxy)-2-phenyl-4H-chromen-4-one - 7-(4-((1H-imidazol-2-yl)thio)butoxy)-2-phenyl-4H-chromen-4-one - 7-(4-(1H-1,2,4-triazol-1-yl)butoxy)-2-phenyl-4H-chromen-4-one - 7-(4-(2-methyl-5-nitro-1H-imidazol-1-yl)butoxy)-2-phenyl-4H-chromen-4-one - 7-(4-(5-methyl-1H-tetrazol-1-yl)butoxy)-2-phenyl-4H-chromen-4-one - 7-(4-bromobutoxy)-2-phenyl-4H-1-benzopyran-4-one - 7-bromo-6-difluoromethylphosphonate 3-naphthalenenitrile 50% inhibition at 230 nM for wild-type, at 886 nM for mutant S295F 7-chloro-6-[(2-morpholin-4-ylethyl)amino]quinoline-5,8-dione - 7-hydroxy-2-(1-(4-methoxybenzyl)-1H-imidazol-4-yl)-4H-chromen-4-one - 7-hydroxy-2-(1-(4-methoxybenzyl)-1H-imidazol-5-yl)-4H-chromen-4-one - 7-hydroxy-2-(1-pentyl-1H-imidazol-2-yl)-4H-chromen-4-one - 7-hydroxy-2-(1-pentyl-1H-imidazol-4-yl)-4H-chromen-4-one - 7-hydroxy-2-(1-pentyl-1H-imidazol-5-yl)-4H-chromen-4-one - 7-hydroxy-2-(1-propyl-1H-imidazol-2-yl)-4H-chromen-4-one - 7-hydroxy-2-(1-propyl-1H-imidazol-4-yl)-4H-chromen-4-one - 7-hydroxy-2-(1-propyl-1H-imidazol-5-yl)-4H-chromen-4-one - 7-hydroxy-2-(1H-imidazol-2-yl)-4H-chromen-4-one - 7-hydroxy-2-(1H-imidazol-4-yl)-4H-chromen-4-one - 7-hydroxy-2-(4'-hydroxyphenyl)-3-[(1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one - 7-hydroxy-2-(4'-hydroxyphenyl)-3-[(3'',4''-dihydroxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one - 7-hydroxy-2-(4'-hydroxyphenyl)-3-[(3''-carboxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one - 7-hydroxy-2-(4'-hydroxyphenyl)-3-[(4''-carboxy-3''-hydroxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one - 7-hydroxy-2-(4'-hydroxyphenyl)-3-[(4''-hydroxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one - 7-hydroxy-2-(4-hydroxybenzyl)-4H-chromen-4-one 10% inhibition of LMW-PTP isozymes 1 and 2,no inhibition of PTP-B1, at 0.015 mM 7-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one - isolated from the CH2Cl2 extract of Glycyrrhiza inflata 7-hydroxy-2-(4-hydroxyphenyl)-3-[(3',4'-dihydroxy-1,1-biphenyl-3-yl)methyl]-4H-1-benzopyran-4-one 60% inhibition of LMW-PTP isozyme 2, 25% inhibition of LMW-PTP 1, and 50% inhibition of PTP-B1, at 0.02 mM 7-hydroxy-2-(4-hydroxyphenyl)-3-[(4'-carboxy-3'-hydroxy-1,1-biphenyl-3-yl)methyl]-4H-1-benzopyran-4-one 5% inhibition of LMW-PTP isozyme 2, 10% inhibition of LMW-PTP 1, and 59% inhibition of PTP-B1, at 0.02 mM 7-hydroxy-2-(4-hydroxyphenylethyl)-3-[(1,1-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one 7-hydroxy-2-(4-hydroxyphenylmethyl)-3-[(1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one 7-hydroxy-2-(4-hydroxyphenylpropyl)-3-[(1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one 10% inhibition of LMW-PTP isozymes 1 and 2,no inhibition of PTP-B1, at 0.015 mM 7-hydroxy-2-[1-[(4-methoxyphenyl)methyl]-1H-imidazol-2-yl]-4H-1-benzopyran-4-one - 8-(2-[4-[(E)-2-carboxyethenyl]phenyl]-1,3-thiazol-4-yl)dibenzo[b,d]furan-4-carboxylic acid - 8-acetyl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid 8-benzyl-4-oxo-4H-chromene-3-carbaldehyde 50% inhibition at 0.018 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases 8-bromo-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid 8-bromo-4-oxo-6-(2-phenyl-1-benzothien-3-yl)-4H-chromene-3-carbaldehyde 50% inhibition at 0.0078 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases 8-bromo-6-(10-bromo-9-anthryl)-4-oxo-4H-chromene-3-carbaldehyde 50% inhibition at 0.011 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases 8-bromo-6-(2-bromo-1-benzothien-3-yl)-4-oxo-4H-chromene-3-carbaldehyde 50% inhibition at 0.0082 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases 8-bromo-6-dibenzo(b,d)thien-1-yl-4-oxo-4H-chromene-3-carbaldehyde 50% inhibition at 0.010 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases 8-bromo-6-dibenzo(b,d)thien-4-yl-4-oxo-4H-chromene-3-carbaldehyde 50% inhibition at 0.016 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases 8-hydroxy-3-methoxy-11-oxo-1-pentanoyl-6-pentyl-11H-dibenzo[b,e][1,4]dioxepine-7-carboxylic acid - isolated from a methanol extract of the Antarctic lichen Stereocaulon alpinum abietic acid a nonpolar inhibitor and weak mixed-type inhibitor of PTP1B, inhibits the enzyme by binding to its active site in a nonsubstrate-like manner that stabilizes the catalytically essential WPD loop in an inactive conformation, modelling of enzyme binding
