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In its role as a bisphosphoglyceromutase, the enzyme competes with PGK for 1,3-BPG as a substrate

Low levels of B12 fatigue and weakness constipation loss of appetite and weight loss problems with balance depression problems with thinking a sore mouth or tongue In infants, signs of a deficiency include: not growing or developing at the expected rate problems with movement megaloblastic anemia Anemia and neurological problems can lead to further symptoms and complications