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Ann Rheum Dis (2015) 74:166775

By integrating insights from basic science research with clinical observations, this review aims to advance the understanding of the comorbidity of CVDs and cognitive impairment and to identify potential therapeutic targets with cross-disease applicability

The depletion of tryptophan in the local environment impairs effector T cell function, while kynurenine degradation products can suppress tumor immunity by inducing the generation of Foxp3+ regulatory T cells (Tregs) (Sharma et al., 2007)