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ST: Conceptualization, Formal analysis, Writing review & editing

However, its impact on endosomal escape requires careful optimization, as PEG can hinder LNP fusion with endosomal membranes, a phenomenon often referred to as the PEG dilemma 174,175,176

In comparison to other bioactive compounds, such as small molecule drugs [14], nucleic acids [15], ions [16], nanoparticles [17], and micro/nanostructures [18], BAPPs target and interact with specific receptors with limited side effects and have highly complex functions [19, 20]

PMID: 8319212

Its a concurrent feature of obesity and related conditions like diabetes