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Multivariate and univariate analyses were performed in a MATLAB environment in order to identify APAP metabolites after APAP, APAP-Cys, NAC-APAP, and APAP-SG exposures as described in the supplementary information

5-Amino-1MQ was identified as a potent NNMT inhibitor in work published by the Bhatt Lab and collaborators, with subsequent preclinical studies demonstrating that NNMT inhibition in diet-induced obese mice reduced body weight, decreased adipose tissue mass, and improved metabolic parameters including insulin sensitivity and plasma lipids

Glutathione is a key player in the livers "Phase II" detoxification pathway

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We investigated the fate of hepatic stellate cells under necroptotic stimuli