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doi: 10.3389/fimmu.2023.1211231 Received 24 April 2023 Accepted 10 July 2023 Published 31 July 2023 Volume 14 - 2023 Edited by Adnane Achour, Karolinska Institutet (KI), Sweden Reviewed by Jos Luis Maldonado-Garca, National Autonomous University of Mexico, Mexico

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However, this physiological structure presents a challenge for transdermal drug delivery, limiting the bioavailability of drugs administered through the skin