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Given the ongoing interest in antioxidants and glutathione in particular as potential therapeutic targets in depression, we have undertaken a meta-analysis to summarise current work in this field and to highlight the contribution of glutathione to the antioxidant theory of depression

MPO is a hemeiron-containing enzyme implicated in the pathology of chronic inflammation that, in the presence of hydrogen peroxide and chloride ions, will destroy its heme prosthetic group to generate free iron (Maitra et al

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However, its efficacy is often limited by incomplete symptom relief and side effects, especially in older populations 5,6,7,8,9