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Our methionine input is computed to be 103 M/h consistent with experimental measurements [26, 52] and our cysteine input into the system is 70 M/h

Fiji: an open-source platform for biological-image analysis

Loss of GPX4 activity might activate other compensatory genes or pathways in response to increased ROS, such as FSP1 [42, 43]

The impact of homocysteine on the function of thioretinaco ozonide within mitochondria and endoplasmic reticulum leads to excitotoxicity, oxidative stress, endothelial dysfunction, and inflammation [39]

The following table lists the values and weights used for ensemble modelling for each kinetic parameter: As per the protocol, following the collection of values from literature, we calculated the mode and spread of the values, which were then used to estimate the mean and standard deviation of the log-normal distribution for each parameter