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These alterations not only initiate local inflammatory and metabolic disturbances but also propagate systemic effects through microbial translocation and immune modulation

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In the same exposure conditions, less than 3.5 pmol HEV/g globinunder 20% of background HEV (approximately 20 pmol/g globin) observed in non-exposed populationscan be attributed to ET-derived EtO, suggesting unidentified HEV sources