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Further research is needed to optimize the efficacy and safety of these therapeutic strategies and to translate preclinical findings into clinical applications for individuals with COPD (116)

1 Introduction Drug metabolism is the process by which the body processes pharmaceuticals from initial absorption to distribution to action to their final removal ( Drug Metabolism occurs in two phases in the liver: phase I and phase II ( The CYP450 family is widely diverse, with multiple isoforms such as CYP3A4, CYP2D6, CYP2C9, and CYP1A2, which promote the biotransformation of a broad range of xenobiotics and endogenous compounds ( Recently, the concept of the exposome has appeared as a potential framework for interpreting how the environment shapes health and diseases throughout life

In the current study, none of the 12 overlapping metabolites was significantly correlated with cTnI, although four (2-methoxyhydroquinone sulfate, 3-methoxycatechol sulfate, creatine, and isobutyrylcarnitine) were nominally significant

Baseline GR level was not suppressed but rather increased with due time, and more so in the treatment group

doi: 10.18632/aging.100683 32 ElustondoP