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I think thats gotta be the mission statement: put the money on the screen

A subset of cultured cells expressed GLP- 1 receptor, and mice with a-cell specific GLP- 1 receptor knockout have mild glucose intolerance and higher glucagon secretion in response to glucose challenges than animals of the wild type, which may indicate that GLP- 1 directly affects this cell [69]

This article lays out the Australian model in plain terms, then compares it to the US Investigational New Drug (IND) application and the EU Clinical Trial Application (CTA)

[DOI] [PMC free article] [PubMed] [Google Scholar] 116.Verdin E

Lancet 404 , 949961 (2024)