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The sensitive mass spectrometry strategy has been built to detect furans reactive metabolites plus GSH conjugates, such as neutral loss scanning of 290.0573 Da in the positive ionization mode, and precursor ion scanning of m/z 143.0462 + in the negative ionization mode (Wang et al., 2014b)

[DOI] [Google Scholar] 87.Phillips M.L., Kupfer D.J

demonstrated that the combination of cisplatin with nab-paclitaxel/gemcitabine resulted in improved clinical outcomes, including mOS of 19.2 months and a mPFS of 11.8 months in patients with advanced BTC (NCT02392637) [33], indicating enhanced efficacy and potential to mitigate resistance

This sustainable solution reduces environmental impact while ensuring barrier protection, sterility, and precise dosing for regulated use.

Future work should adopt longitudinal designs to assess therapeutic effects across temporal windows