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These microbial and metabolic shifts collectively suppress NLRP3 inflammasome activation and downstream NF-B signaling in the CNS, resulting in attenuated neuroinflammation and enhanced cognitive performance

Autoimmune diseases, once considered rare, now affect a substantial proportion of the global population and arise from a breakdown of immune tolerance, whereby adaptive and innate responses fail to discriminate self from non-self (1)

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IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells