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Researchers have shown improvements in healthspan-related measures in mice, but no study has demonstrated lifespan extension in humans, and the evidence remains preliminary even in animal models

Professor Ngs research contributions to AOD-9604 development include: Synthesis and characterization of the modified C-terminal growth hormone fragment with enhanced stability Design of the tyrosine N-terminal modification to improve peptide stability and half-life Preclinical studies demonstrating lipolytic effects in obese animal models Advancement of the peptide through multiple phases of clinical development Investigation of mechanisms underlying beta-3-adrenergic receptor modulation His work established the foundation for understanding peptide-based approaches to metabolic regulation, though clinical translation ultimately proved unsuccessful

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This review highlights the potential of metabolomics, proteomics, miRNA, and MRI studies to advance our understanding of chronic diseases, and identifies key areas, such as the impact of altered lipid and energy metabolism, that warrant further investigation