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Extracellular NAMPT and NAPRT: Adipocytokines and DAMPs In addition to a direct effect on NAD and its metabolites, the enzymes involved in synthesis of NAD also have important extracellular functions, as summarized in Figure 3

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In the last recent years, the association between low serum levels of A1AT and the development of RA has been identified, particularly in relation to specific A1AT genotypes

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Luciferase reporter assays showed that ectopic expression of Np63, but not the transactivation defective mutant (R304W), promoted reporter activity of PHGDH-Gluc, PSAT1-Gluc, PSPH-Gluc, SLC1A4-Gluc (Fig