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For example, in GPX4 + / mice, exposure to cigarette smoke increases the infiltration of immune cells (e.g., macrophages and lymphocytes), DAMPs (e.g., HMGB1) and cytokine (e.g., IL1A, IL33 and TNF) production in bronchoalveolar lavage fluid

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Topiramate has been shown to be an effective and well-tolerated prophylactic medication for the treatment of migraine (Afshari et al., 2012), but the mechanism has not yet been clarified

M.El-KaraksyH.HosnyH.GhobrialC.et al (2018)