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and synthetic compounds (chlormethiazole and YH-439 137,284 ) can prevent alcohol-induced oxidative stress and the formation of various adducts, including AA adducts 137 and AA-MAA adducts 53,285 , although the preventive effects of all these dietary compounds on AGE-associated adduct formation have not been specifically evaluated

Similarly, QUE enhanced the killing effect of DOX on P388 leukemia cells by inhibiting the expression of NF-B, p65, and Bcl-2 but by activating Bax and Caspase-3 (52)

These signals activate intracellular HIF-1, NF-B, caspase-8, and other pathways to promote the expression of NLRP3/caspase-1 [127, 128]