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[13] Fanton S, Sandstrm A, Tour J, Kadetoff D, Schalling M, Jensen KB, Sitnikov R, Ellerbrock I, Kosek E

In ischaemic stroke, experimental models have demonstrated that Huperzine A attenuates neuronal apoptosis by upregulating Bcl-2, downregulating pro-apoptotic Bax and p53, and inhibiting caspase-3 activation, thereby preserving mitochondrial membrane potential and promoting neuronal survival under hypoxic conditions [35, 44, 46]