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Toronto-Dominion Bank

Screening technique of the present invention comprises that cell is contacted and measure said test compounds with test compounds regulate expression and/or the active ability of treatment target of the present invention in cell.The expression of treatment target of the present invention and/or activity can be like described herein measuring.The expression of treatment target of the present invention and/or active use also capable of using conventional method well known by persons skilled in the art are measured.In one embodiment, increase the expression and/or the active ability SCREENED COMPOUND of treatment target of the present invention based on it.In one embodiment, the expression and/or the active ability that are selected from proteinic treatment target listed among the table 1-28 (for example, table 2-4 and 6-28) based on its increase are selected chemical compound, and wherein said treatment target is raised (for example, showing that positive multiple changes) by CoQ10.In one embodiment, select chemical compound based on its expression and/or active ability that reduces treatment target of the present invention.In one embodiment, the expression and/or the active ability that are selected from proteinic treatment target listed among the table 1-28 (for example, table 2-4 and 6-28) based on its minimizing are selected chemical compound, and wherein said treatment target is by CoQ10 downward modulation (for example, showing that negative multiple changes)

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Prepare a clean, well-lit workspace with all supplies within reach