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For example, the microRNA (miR)-127-3p/MAPK/AKT/mechanistic target of rapamycin (mTOR)/p70S6K axis has been shown to simultaneously stimulate tumor cell autophagy and polarize macrophages toward an M1 phenotype (6)

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140 (6), 413417 (2002) Hong, R.W., Rounds, J.D., Helton, W.S., Robinson, M.K., Wilmore, D.W.: Glutamine preserves liver glutathione after lethal hepatic injury

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Specific mechanisms under investigation include critical pathways involved in the generation of and protection against oxidative stress