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TMA syndromes require rapid intervention with plasmapheresis, immunosuppressive agents (corticosteroids), or complement-inhibiting therapies (e.g., eculizumab) due to their natural pathophysiology of endothelial damage and complement dysregulation

Both animal and clinical studies found no adverse effects at the levels used in cosmetics

Billing modifier 50 without clinical documentation of truly bilateral, separate-needle injections is unsupportable

Constipation, while less common than diarrhea, may also occur and can be particularly problematic in patients with pre-existing constipation issues