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This results in pain, stiffness, and swelling

However, it is known that ER predominates in dermal cells and the expression of ER declines after menopause with the loss of collagen and elastin

doi:10.1016/S0140-6736(17)30933-9

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If the PERC rule is 1 or greater, then the Wells criteria should be utilized to determine if there is a low, intermediate, or high probability of pulmonary embolism