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13,14,15 Additionally, impaired neurotrophic support and autoimmune mechanisms may further exacerbate neuronal degeneration

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Their implication in CIPN through the overload of Ca 2+ entry has been demonstrated (Hill and Oliver, PKC enzyme: Apart from the involvement of PKC on the induction of oxidative stress in neurons, both human and animal studies have linked this enzyme to several pain types through excessive Ca 2+ entry and cation channel activation (Carozzi et al., 2009)