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The European Human Biomonitoring Initiative (HBM4EU) - aimed to further establish HBM as important tool for determining population exposure to chemicals and as part of health-related risk assessments - agreed on a strategy for deriving Human Biomonitoring Guidance Values (HBM-GVs) (Louro et al

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Large-scale trials are only available for BH 4 , sepiapterin or sapropterin in phenylketonuria (Muntau et al., 2024), an autosomal recessive disorder caused by deficiency of phenylalanine hydroxylase, leading to hyperphenylalaninemia, developmental delay, behavioral problems, and reduced quality of life ( Approaches with preclinical evidence only Promoting transcriptional regulation of eNOS Several compounds have been identified to enhance eNOS transcription and promote NO production

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Yuan Ju, [email protected]