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Reactions were performed with 5 M histone H3 (histone L-arginine) substrate, 1 M radiolabeled S-adenosyl-L-[methyl- 3 H] methionine (SAM) co-substrate, and recombinant human PRMT3 enzyme

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The use of bispecific reagents has found wide clinical applications because of its simplicity andequally importantlower costs (74)

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