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Anticancer Drugs 19:721727 Rademaker-Lakhai JM, Terret C, Howell SB, Baud CM, De Boer RF, Pluim D, Beijnen JH, Schellens JH, Droz J (2004) A Phase I and pharmacological study of the platinum polymer AP5280 given as an intravenous infusion once every 3 weeks in patients with solid tumors

With the commercializing of the human growth hormone (hGH), a clinical study, which correlated the level of aggregates within formulations and the immune responses of patients were explored