event-driven endpoint Obstructive Sleep Apnea Status: Phase 3 Planned Focus: OSA severity reduction (apnea-hypopnea index) with CagriSema-induced weight loss Population: Adults with moderate-severe OSA and obesity Timeline: Expected enrollment 2024-2025 NASH/MAFLD Status: Phase 2 Ongoing Focus: Hepatic steatosis, inflammation, and fibrosis improvement Population: Adults with biopsy-confirmed NASH/MAFLD Timeline: Results expected 2025 Heart Failure with Preserved EF Status: Preclinical Planning Focus: HFpEF outcomes in obese patients following substantial weight loss Rationale: Obesity-HFpEF phenotype may benefit from profound weight reduction Timeline: Early development phase Pediatric Obesity Status: Phase 2 Planning Focus: Safety, tolerability, and efficacy in adolescents (12-18 years) Population: Adolescents with obesity (BMI 95th percentile) Timeline: Expected initiation 2025 Oral Formulation Development Status: Preclinical Focus: Oral bioavailability enhancement for cagrilintide using absorption enhancers Rationale: Oral delivery could improve accessibility and adherence Timeline: Research phase
Semax 5mg Vial Best for: General cognitive support, testing tolerance, or short 4-week cycles Reconstitution: 3.0 mL bacteriostatic water ~1.67 mg/mL concentration Dosing at 1.67 mg/mL: 1 unit = 0.01 mL 16.7 mcg 300 mcg dose: 18 units (0.18 mL) 500 mcg dose: 30 units (0.30 mL) Vials needed for 4-week cycle @ 0.5 mg/day: 3 vials Semax 10mg Vial Best for: Extended protocols, cost-effective bulk research, or higher dose regimens Reconstitution: 3.0 mL bacteriostatic water ~3.33 mg/mL concentration Dosing at 3.33 mg/mL: 1 unit = 0.01 mL 33.3 mcg 300 mcg dose: 9 units (0.09 mL) 500 mcg dose: 15 units (0.15 mL) Vials needed for 8-week cycle @ 0.5-0.8 mg/day: 4 vials For 10unit administrations, consider 30 or 50unit insulin syringes for improved readability
& Hnenberger, P
The platform offers tools and guides addressing every aspect of peptide handling from receipt through final use
Although this represents a continued decline compared with 2023 and 2024, the overall portfolio was notably diverse and highly innovative
