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In either embodiment, when only a portion of the variable or constant region is replaced, the resulting chimeric antibody can define the same antigen and/or have the same effector function yet be altered or improved so that the chimeric antibody may demonstrate a greater antigen specificity, greater affinity binding constant, increased effector function, or increased secretion and production by the transfected antibody producing cell line, etc

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So, lets break this down, step by step, with the precision your work deserves

In contrast, after the addition of SB431542, a TGF signalling inhibitor, to the high-glucose medium, -SMA expression in PSCs decreased to a nearly undetectable level

Yau T, Tai D, Chan SL, Huang YH, Choo SP, Hsu C, et al