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Though several factors contribute to poor kidney healthincluding autoimmune conditions, chronic hypertension, and diabetesthere is also evidence that low vitamin D levels contribute to poor kidney function, says Vicki Shanta Retelny, RDN, author of Total Body Diet for Dummies

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Concentrations of BHB ranging from 0.5 to 3 mmol/L may confer beneficial effects on tissue metabolism, a state commonly referred to as nutritional ketosis

This triggers downstream signaling pathways (e.g., NF-B and MAPK), driving the massive release of pro-inflammatory cytokines, including IL-1, IL-6, and TNF- (167170)

Conclusion: In PWH, MASLD severity is associated with gut dysbiosis and a shift in metabolic function of the gut microbiota