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Abbreviations Used BAL bronchoalveolar lavage CySS cystine DNTB 5,5-dithiobis-(2-nitrobenzoic acid) ELF epithelial lining fluid FAD flavin adenine dinucleotide GPX glutathione peroxidases GR glutathione reductase GRX glutaredoxins GSH glutathione, reduced (thiol) form GSNO nitrosoglutathione GSSG glutathione disulfide GST glutathione-S-transferase H 2 O 2 hydrogen peroxide HPLC high-performance liquid chromatography IL interleukin MetO methionine sulfoxide MMA mild-to-moderate asthma NF-B nuclear factor kappa B NO nitric oxide radical NO 2 nitrite NO 3 nitrate Nrf2 nuclear factor (erythroid-derived 2)-like 2 O 2 superoxide anion ONOOH peroxynitrous acid OONO- peroxynitrite PRX peroxiredoxins RANTES regulated on activation, normal T-cell expressed and secreted RNS reactive nitrogen species ROS reactive oxygen species SA severe asthma -SeH selenocysteine (selenol) residue SeOH selenenic acid SeSG selenenyl sulfide adduct -SG reactive glutathione -SH sulfhydryl SOD superoxide dismutase TGF1 transforming growth factor beta-1 Th2 T helper type 2 TRX thioredoxin Acknowledgment This work was supported in part by RO1 NR012021

Further investigation is needed of protocols to implement and achieve these CHO availability manipulations and how they might be best optimized within altitude training