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PubMed, Engevik, Melinda A., et al

Unlike some other substances that might stimulate GH release, Ipamorelin is designed to avoid significantly impacting other hormonal systems

They promote macrophage polarization to the M2 anti-inflammatory phenotype, inhibit inflammatory pathways, and may improve skin barrier function, offering theoretical benefits in RA, IBD, and psoriasis

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Similarly, peroxisome proliferator-activated receptor (PPAR)- agonists such as fenofibrate promote fatty acid oxidation, which may help clear the lipid accumulation associated with mitochondrial dysfunction and reduce inflammation-driven atherosclerosis (159)