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First introduced in 1927, insulin shock therapy was devised by Manfred Sakel, an Austrian neuropsychologist, after he observed an improvement in the psychiatric condition of one of his patients with a morphine addiction when he recovered from a hypoglycaemic coma accidentally induced by too much insulin

[DOI] [PubMed] [Google Scholar] 85.Trotti D., Rossi D., Gjesdal O., Levy L.M., Racagni G., Danbolt N.C., Volterra A

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However, the mechanism by which NAC-mediated VWF/p38 MAPK affects pulmonary fibrosis in COPD involving the immune response and EMT is still poorly understood, highlighting a major gap in knowledge given that NAC-mediated VWF/p38 MAPK may be of significance to pulmonary fibrosis in COPD