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Calpain inhibition can abolish MDR (378, 379), and calpain inhibitors, such as MDL-28170 (380) and calpeptin (381), can reduce MPs and enhance the sensitivity to trastuzumab in breast cancer (382)

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This is consistent with research conducted in aged roosters that a ratio of 6.25: 1 omega-6/omega-3 PUFAs dietary supplements is the optimal concentration for improved semen quality and reproductive performance in aged roosters, while a ratio below 6.25: 1 may increase the degree of sperm lipid peroxidation and reduced reproductive outcomes (98)

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PARKIN ubiquitinates some proteins on the surface of mitochondria that are then recognized as autophagy adaptor proteins and delivered to the autophagosome (Chen and Dorn, 2013

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