doi: 10.1016/j.phrs.2020.105297 24 ZhaoTZhangYMuSParkJPBuHLengXet al
Apigenin treatment increased the production of ROS and the expression of endoplasmic reticulum stress proteins in VK2/E6E7 and End1/E6E7 cells
Metabolic parameters including energy expenditure, RER, locomotor activity, and cumulative food intake were continuously recorded and analyzed
Landscapes Health & Medical Sciences (AREA) Chemical & Material Sciences (AREA) Life Sciences & Earth Sciences (AREA) General Health & Medical Sciences (AREA) Medicinal Chemistry (AREA) Public Health (AREA) Veterinary Medicine (AREA) Pharmacology & Pharmacy (AREA) Animal Behavior & Ethology (AREA) Organic Chemistry (AREA) General Chemical & Material Sciences (AREA) Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA) Chemical Kinetics & Catalysis (AREA) Engineering & Computer Science (AREA) Bioinformatics & Cheminformatics (AREA) Epidemiology (AREA) Diabetes (AREA) Hematology (AREA) Heart & Thoracic Surgery (AREA) Immunology (AREA) Cardiology (AREA) Endocrinology (AREA) Gastroenterology & Hepatology (AREA) Proteomics, Peptides & Aminoacids (AREA) Pulmonology (AREA) Urology & Nephrology (AREA) Reproductive Health (AREA) Ophthalmology & Optometry (AREA) Biomedical Technology (AREA) Pregnancy & Childbirth (AREA) Neurosurgery (AREA) Pain & Pain Management (AREA) Rheumatology (AREA) Virology (AREA) Hospice & Palliative Care (AREA) Otolaryngology (AREA) Toxicology (AREA) Vascular Medicine (AREA) Gynecology & Obstetrics (AREA) Neurology (AREA) Abstract Description Alle hherorganisierten vielzelligen lebenden Systeme, auch der Mensch,decken den Energiebedarf ihrer Zellen und Gewebe nach dem Prinzip der biologischen Oxidation.All highly organized multicellular living systems, including humans, cover the energy requirements of their cells and tissues according to the principle of biological oxidation
The resulting energy deficits and accumulation of damaged mitochondria contribute to neuronal dysfunction and apoptosis, particularly in metabolically demanding regions such as the hippocampus
