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Eur J Dermatol 23(6):912913

These events collectively result in mitochondrial dysfunction, elevated ROS, and impaired protein clearance, the triad that drives S misfolding and aggregation

Several substituted derivatives of hydroxylamine are known and, it has been shown that one of them, N-tert-butyl hydroxylamine, protects cells from OS and mitochondrial damage in an in vitro model of age-related macular degeneration (AMD) [285]

In a healthy system, intracellular glutathione immediately neutralizes these free radicals, protecting the delicate mitochondrial membranes from lipid peroxidation and structural damage