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(Papp) : Papp = dQ/dt x 1/A C 0 The apparent transmission coefficient (Papp) of all polypeptides was calculated using the following equation: Papp = dQ/ 0 dQ/dt dt Caco-2 , C 0 0 , A .If dQ/dt is the amount of solute transported across the Caco-2 barrier at time dt, C 0 is the solute concentration in the apical compartment at 25 mg/mL, Caco-2 :3 (P app = 10.3).Sodium kenodeoxycholate had the highest permeability of the SEQ ID NO: 3 peptide across the Caco-2 cell layer at 25 mg/mL (P app = 10.3)

[PubMed] [Google Scholar][20] Chen HC, Wiek J, Gupta A, Luckie A, Kohner EM

It has anti-inflammatory properties by reducing synovitis and prevent proinflammatory cytokine up-regulation in arthritis

Summary: The recommended daily dose of vitamin B12 for UK adults aged 1964 years is 1.5 micrograms, whilst treatment doses for deficiency range from 50 g to 1,000 g daily or via intramuscular injection