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Like other organs, the nervous system is composed of specific cell types with distinct metabolic needs and characteristics, which can lead to mitochondrial heterogeneity (Rangaraju et al., 2019

Rahman I (2012) Pharmacological antioxidant strategies as therapeutic interventions for COPD

Causes of vitamin B12 deficiency include food cobalamin malabsorption (low intestinal absorption of the vitamin from food) due to intrinsic factor receptor deficiency (a substance needed for absorption of B12), impaired calcium availability, gastrointestinal disorders such as chronic gastritis, Crohns disease, and other bowel inflammatory disorders, surgery on the digestive tract such as total or partial gastrectomy, or autoimmune conditions

Epitalon is listed on the World Anti-Doping Agency (WADA) prohibited list

This process is further amplified by the lipid-rich TME, where CD36 upregulation on CD8 T cells is correlated with increased expression of the exhaustion markers PD-1, TIM-3, and LAG-3 [53]