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Hepsin as a potential therapeutic target for alleviating acetaminophen-induced hepatotoxicity via gap-junction regulation and oxidative stress modulation

1) Cell type- and nephron segment-specific susceptibility: The kidney is a highly heterogeneous organ, with distinct nephron segments [PT, distal tubule (DT), collecting duct (CD)] and cell types (podocytes, mesangial cells, interstitial fibroblasts, and endothelial cells) exhibiting divergent ferroptosis susceptibility

Seki S, Kitada T, Yamada T, Sakaguchi H, Nakatani K, Wakasa K

Libraries were prepared using the Kapa HTP kit (Illumina, San Diego, CA, United States) and capture was performed using the SeqCap EZ Human Exome Library v3.0 (Roche NimbleGen Madison, WI, United States)

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