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Mechanistically, these epigenetic findings align with one-carbon metabolism

doi: 10.1016/j.mito.2020.05.010 88 RigoA.StevanatoR.Finazzi-AgroA.RotilioG

Interestingly, gastric sleeve surgery itself increases endogenous GLP-1 levels, which contributes to its metabolic benefits

GSTT1, GSTM1

In this study, oral administration of Pg in mice caused a significant upregulation of FMO3 gene expression in the liver compared to the other three groups