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In vivo models of primary brain tumors: Pitfalls and perspectives

Symptoms are often the beginning of the investigationnot the end

This signaling pathway in turn cross-talks with the T cell receptor (TCR) signaling pathway, resulting in the enhanced effector function observed in MAO-A-KO T cells ( Figure 1A ) (5)

Conclusion: This study revealed a critical role of CRL3 in hepatic metabolic regulation and identified NRF2-mediated NADH-reductive stress as a previously unrecognized downstream effector modulating the development of hepatic steatosis

LAT2 ( SLC7A8 ), another important BCAA transporter, has been reported to be abnormally expressed in cancers (Wang and Holst, 2015)