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Furthermore, spinal caspase-3 cleavage is required for axonal degeneration, mitochondrial dysfunction, oxidative stress and apoptosis in the pathogenesis of CIPN after intraperitoneal vincristine stimulation in mice (Yu et al., 2021)

Abstract Acetyl-CoA synthetases (Acs) have emerged as drug targets for the treatment of cancer, metabolic diseases as well as fungal and parasitic infections

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3,4 Latent TGF-s are activated by various pathways in vivo Although TGF- ligand and receptors are ubiquitous in many types of cells, their biological effects are usually restricted at sites where the ligand is activated