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Critically, we demonstrated that suppression of SLC7A11 transcription results from mut-p53 binding and interfering with the activity of the master antioxidant transcription factor NRF2, a mechanism which is separate from the transcriptional regulation of SLC7A11 by wt-p53 described by Jiang et al

D., & Hooper, D

However, challenges persist, including their potential for aggregation, cytotoxicity under certain conditions, and the complexity of large-scale production

This pathological stretch also activates NF-B, promoting the secretion of pro-inflammatory cytokines such as IL-6/8 and the expression of CD40 and VCAM-1, driving immune cell recruitment and contributing to atherosclerosis progression [214]

All animal handling procedures are in agreement with the ARRIVE guidelines from the National Center for the Replacement, Refinement, and Reduction of Animals in Research (NC3Rs) 19 throughout the experimental period (eight weeks)