All three of these work great, so experiment and see what works best for you
Iminosugars: deoxynojirimycin or a deoxynojirimycin derivative, like N- propyldeoxynojirimycin, N-butyldeoxynojirimycin, N-butyldeoxygalactonojirimycin, N-pently deoxynojirimycin, N-heptyl deoxynojirimycin, N-pentanoyldeoxynojirimycin, N-(5-adamantane-l-ylmethoxy)pentyl)-deoxynojirimycin, N-(5-cholesteroxypentyl)- deoxynojirimycin, N-(4-adamantanemethanylcarboxy-l-oxo)-deoxynojirimycin, N-(4- adamantanylcarboxy- 1 -oxo)-deoxynojirimycin, N-(4-phenantrylcarboxy- 1 -oxo)- deoxynojirimycin, N-(4-cholesterylcarboxy-l-oxo)-deoxynojirimycin, or N-(4-- cholestanylcarboxy- 1 -oxo)-deoxynojirimycin
GCH1 (GTP cyclohydrolase 1) is the rate-limiting enzyme in the biosynthesis of tetrahydrobiopterin (BH4), a potent lipophilic antioxidant that can inhibit ferroptosis 35
(54, 55) (Figure 1), which arguably would have subthreshold benefits for working memory/executive functioning
Based on the findings of Salahshoor et al., the administration of GEN as an antioxidant and a potent phytoestrogen could reduce the morphine-induced injuries through various mechanisms and improve the structure, enzymes, and performance of liver in the groups receiving morphine (Salahshoor et al., 2018)