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Sasaki K, Doi S, Nakashima A, Irifuku T, Yamada K, Kokoroishi K

When injected into Mdr2KO mice, ASO 56 mitigated HSC activation in vivo , reduced levels of circulating proinflammatory cytokines such as IL-6, and decreased F4/80 protein levels in the liver compared to control mice

5.10 Co-formulation and organ-targeted strategies The therapeutic potential of silymarin is limited by its poor oral bioavailability, primarily due to low aqueous solubility and active efflux mechanisms mediated by intestinal transporters, such as BCRP and MRP2

aktivita Cu,Zn-SOD, glutathion S-transferzy a glutathionperoxidzy