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Various structural alterations were made at the N-terminal such as substitution of D-norleucine for L-norleucine, N-acetylation of norleucine, and replacement of norleucine with GABA in order to improve overall stability by reducing susceptibility to aminopeptidases

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al

Lab demonstrations have proved that they are at least capable of vectoring murine typhus, rickettsial pox, tularemia, plague, coxsackievirus, and Q fever, although it has not been known to do so outside the lab

However, visible changes usually take time

Its ability to induce cell death in cancer cells without harming normal cells presents a promising direction for cancer therapeutics