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The Impact of KD on PD treatment Levodopa remains the first-line therapy for PD, however, its use comes with significant challenges

It is important to note some limitations of our study

Cytoplasmic protein aggregates, a pathological feature of ALS, disrupt key cellular degradation mechanisms, including both the ubiquitin-proteasome system and autophagy pathways, resulting in catastrophic failure of protein homeostasis

Upregulation of AKT promoted the expression of Pirin and subsequent activation of nuclear factor erythroid 2related factor 2 (Nrf2) and the NF-B signaling cascade, protecting cells from OS effects on viability [53]

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